ABSTRACT
Evidence suggests that metalloprotease expression may affect the biological behavior of odontogenic lesions. This study was conducted to review the literature about the role of metalloproteases in the development of odontogenic lesions. A search was carried out using one database, MEDLINE, via PubMed. Only articles written in English were included. Abstracts of all articles retrieved in the electronic search were evaluated for their relevance. Three articles met inclusion criteria. They analyzed the role of MMP-2, MMP-8 and MMP-13 in radicular cysts, dentigerous cysts and keratocystic odontogenic tumors, and of MMP-1, MMP-7 and MMP-27 in keratocystic odontogenic tumors. The immunostaining technique used for all studies was similar, differing only in type of staining used. Different immunoreactivity results were found in the studies. The pattern of metalloprotease expression in odontogenic lesions was different from the pattern found in other lesions. In the studies analyzed, there was a significant positive immunoreactivity for metalloproteases in odontogenic lesions, particularly in keratocystic odontogenic tumors, a finding that may explain KCOT aggressiveness.
Evidências sugerem que a expressão das metaloproteinases podem afetar o comportamento biológico das lesões odontogênicas. Esse estudo foi conduzido a fim de revisar a literatura sobre o papel das metaloproteinases no desenvolvimento das lesões odontogênicas. A pesquisa foi realizada utilizando a base de dados do MEDLINE, via PUBMED. Somente artigos escritos em língua inglesa foram aceitos. Os resumos de todos os artigos encontrados na busca foram avaliados de acordo com sua relevância. Três artigos preencheram os critérios de inclusão. Eles analisaram o papel da MMP-2, MMP-8 e MMP-13 nos cistos radiculares, cistos dentígeros e nos tumores odontogênicos ceratocísticos (TOC) e MMP-1, MMP-7 e MMP-27 no TOC. A técnica imunoistoquímica utilizada por todos os estudos foi similar, diferindo somente pelo tipo da coloração utilizada. Diferentes imunomarcações foram encontradas nos estudos. O padrão da expressão das metaloproteinases nas lesões odontogênicos variou entre as lesões. Nos estudos analisados, houve uma imunomarcação positiva, significante estatiticamente, das metaloproteinases nas lesões odontogênicas em especial nos TOCs, o que pode explicar a agressividade dessas lesões.
Subject(s)
Odontogenic Cysts , Immunohistochemistry , Extracellular Matrix , Matrix Metalloproteinases , Odontogenic TumorsABSTRACT
OBJECTIVE: The aim of this study was to evaluate if there is correlation between perception of facial esthetic and divine proportion, verifying if most attractive faces are closer to and less attractive faces are more distant to this proportion. METHODS: Standard facial photographs (frontal and lateral) in natural head position were taken of a sample of 85 Brazilian Caucasian women, with mean age of 23 years and 9 months. The photographs were evaluated by 5 orthodontists, 5 artists and 5 laymen and were classified, according to their subjective analysis of facial esthetic, in pleasant, acceptable and not pleasant. Frontal photographs were evaluated by divine proportion analysis using the computerized method. RESULTS AND CONCLUSIONS: According to subjective analysis the sample consisted 18.8% of pleasant, 70.6% of acceptable and 10.6% of not pleasant faces. After statistical analysis, a lack of agreement was verified in esthetic facial preferences among the three groups of observers. It was also possible to verify that in this research there was no correlation between perception of facial beauty and divine proportion.